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Neutriceutical Scientific References

1)   New Insights into the causes of alcoholism. Blum, K., Trachtenburg, M. C. (1987) Professional Counselor. 33- 35.

2)   Cocaine Therapy: The ‘Reward Cascade’ Link. Blum, K., Trachtenburg, M. C., Kozlowski, G. P. (1989, Jan/Feb) Professional Counselor. 27-52.

3)   A commentary on neurotransmitter restoration as a common mode of treatment for alcohol, cocaine, and opiate abuse. Blum, K. (1989) Integrative Psychiatry. 6: 99-104.

4)   Neurodynamics of relapse prevention: A neuronutrient approach to outpatient DUI offenders. Brown, R. J. Blum, K., Trachtenburg, M. C. (1990) J. of Psychoactive Drugs. 22: 173-187.

5)   Amino Acid loading and enkephalinase inhibition in familial overeating: Clinical evidence for effectiveness in maintaining weight loss in an open trial controlled two year study. Blum, K., Cull, J. G., Chen, J. H., Garcia-Swan, S., Holder. J. M., Wood, R., Braverman, E. R., Bucci, L. R., Trachtenburg, M. C. (1997, Oct.) Current Therapeutic Research. 58 (10): 745.

6)   Nutritional gene therapy: Natural healing in recovery. Blum, K., Ross, J., Reuben, C., Gastelu, D., Miller, D. K. (2001, February) Counsellor Magazine.

7)   Neurogenetic deficits caused by alcoholism: Restoration. Blum, K., Trachtenburg, M. C. (1988) J. Psychoactive Drugs. 20: 297.

8)   Enkephalinase inhibition and precursor amino acid loading improves inpatient treatment of alcohol and polydrug abusers: Double-blind placebo-controlled study of the nutritional adjunct SAAVE. Blum, et al. (1989) Alcohol. 5: 481.

9)   Reduction of both hunger and withdrawal against advice rate of cocaine abusers in a 30-day inpatient treatment program by the neuronutrient Tropamine. Blum, et al. (1988) Current Ther. Res. 43:1204.

10)  Narcotic antagonists in alcoholism rehabilitation. Blum, K., Braverman, E. R.,  Holder, J. M., Lubar, J. F., Monastra, V. J., Miller, D., Lubar, J. O., Chen, T. J. H., Comings, D. E. (2000, November) J. of Psychoactive Drugs. 32 (Supplement): 50-52.

11)  Section 9: A look to the future. Blum, K., Braverman, E. R.,  Holder, J. M., Lubar, J. F., Monastra, V. J., Miller, D., Lubar, J. O., Chen, T. J. H., Comings, D. E. (2000, November) J. of Psychoactive Drugs. 32 (Supplement): 63-68.

12)  Enkephalinase Inhibition: Regulation of ethanol intake in genetically predisposed mice. Blum, K., et al. (1987) Alcohol. 4: 449.

13)  Improvement of inpatient treatment of the alcoholic as a function of neurotransmitter restoration: A pilot study. Blum, K., et al. (1988) International J. of Addictions. 23: 991.

14)  Drugs abused by human preferentially increase synaptic dopamine concentrations on the mesolimbic system in freely moving rats. Di Chiari, G.D., Imperato, A. (1988) Proceedings of the National Academy of Sc. USA. 85: 5274.

15)  Neuronutrient effects on weight loss on carbohydrate bingers: An open clinical trial. Blum, K., et al. (1990) Current Therapeutic Res. 48: 217.

16)  Clinical evidence for effectiveness of Phencal in maintaining weight loss in an open label, controlled, 2 year study. Blum, K., et al. (1997) Current Therapeutic Res. 56: 745.

17)  Treatment of Attention Deficit Disorder with DL-Phenylalanine. Wood, R., et al. (1985) Psychiatry Research. 16: 21.

18)  Central serotonergic hypofunction in autism: results of the 5-hydroxy-tryptophan challenge test. Croonenberghs J, Wauters A, Deboutte D, Verkerk R, Scharpe S, Maes M. Neuro Endocrinol Lett. 2007 Jul 11;28(4)

19)  Serotonergic disturbances in autistic disorder: L-5-hydroxytryptophan administration to autistic youngsters increases the blood concentrations of serotonin in patients but not in controls. Croonenberghs J, Verkerk R, Scharpe S, Deboutte D, Maes M. Life Sci. 2005 Mar 25;76(19):2171-83.

20)  Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients. Maes M, Vandewoude M, Schotte C, Maes L, Martin M, Blockx P. Acta Psychiatr Scand. 1989 Dec;80(6):584-90.

21)  Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of l-5-hydroxytryptophan. Wang X, Baumann MH, Dersch CM, Rothman RB. Neuroscience. 2007 Aug 10;148(1):212-20. Epub 2007 Jul 12.

22)  5-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin. Turner EH, Blackwell AD. Med Hypotheses. 2005;65(1):138-44.

23)  Effect of orally administered L-tryptophan on serotonin, melatonin, and the innate immune response in the rat. Esteban S, Nicolaus C, Garmundi A, Rial RV, Rodríguez AB, Ortega E, Ibars CB. Mol Cell Biochem. 2004 Dec;267(1-2):39-46.

24)  Selected integrative medicine treatments for depression: considerations for women. Freeman MP, Helgason C, Hill RA. J Am Med Womens Assoc. 2004 Summer;59(3):216-24.

25)  Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders. Agazzi A, De Ponti F, De Giorgio R, Candura SM, Anselmi L, Cervio E, Di Nucci A, Tonini M. Dig Liver Dis. 2003 Aug;35(8):590-5.

26)  5-Hydroxytryptophan: a clinically-effective serotonin precursor. Birdsall TC. Altern Med Rev. 1998 Aug;3(4):271-80.

27)  The effect of oral 5-HTP administration on 5-HTP and 5-HT immunoreactivity in monoaminergic brain regions of rats. Lynn-Bullock CP, Welshhans K, Pallas SL, Katz PS. J Chem Neuroanat. 2004 May;27(2):129-38.

28)  Effect of orally administered phenylalanine with and without glucose on insulin, glucagon and glucose concentrations. Nuttall FQ, Schweim KJ, Gannon MC. Horm Metab Res. 2006 Aug;38(8):518-23.

29)  Oral L-glutamine increases GABA levels in striatal tissue and extracellular fluid. Wang L, Maher TJ, Wurtman RJ. FASEB J. 2007 Apr;21(4):1227-32.

30)  Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Patel AB, Rothman DL, Cline GW, Behar KL. Brain Res. 2001 Nov 23;919(2):207-20.

31)  Chromium yeast supplementation improves fasting plasma glucose and LDL-cholesterol in streptozotocin-induced diabetic rats. Lai MH, Chen YY, Cheng HH. Int J Vitam Nutr Res. 2006 Nov;76(6):391-7.

32)  Tyrosine for the treatment of depression. Gelenberg AJ, Gibson CJ. Nutr Health. 1984; 3(3): 163-73.

33)  Fibromyalgia and the serotonin pathway. Juhl JH. Altern Med Rev. 1998 Oct;3(5):367-75.

34)  Use of neurotransmitter precursors for treatment of depression. Meyers S. Altern Med Rev. 2000 Feb; 5(1): 64-71.

35)  Theoretical and therapeutic potential of indolamine precursors in affective disorders. Wirz-Justice A. Neuropsychobiology. 1977; 3(4): 199-233.

36)  Treatment of brain disease with dietary precursors of neurotransmitters. Growdon JH, Cohen EL, Wurtman RJ. Ann Intern Med. 1977 Mar; 86(3): 337-9.

37)  Amino acid control of neurotransmitter synthesis and release: physiological and clinical implications. Lehnert H, Wurtman RJ. Psychother Psychosom. 1993; 60(1): 18-32.

38)  5-Hydroxytryptophan: a clinically-effective serotonin precursor. Birdsall TC. Altern Med Rev. 1998 Aug;3(4):271-80.

39)  Neurotransmitter precursors and brain function. Conlay LA, Zeisel SH. Neurosurgery. 1982 Apr; 10(4): 524-9.

40)  L-tryptophan in neuropsychiatric disorders: a review. Sandyk R. Int J Neurosci. 1992 Nov-Dec;67(1-4):127-44.

41)  Psychopharmacology of tryptophan. Poitou P, Boulu R. Pathol Biol (Paris). 1977 Oct;25(8):565-71.

42)  L-tryptophan in neuropsychiatric disorders: a review. Sandyk R. Int J Neurosci. 1992 Nov-Dec;67(1-4):127-44.

43)  Tryptophan depletion and its implications for psychiatry. Bell C, Abrams J, Nutt D. Br J Psychiatry. 2001 May;178:399-405.

44)  Rapid depletion of plasma tryptophan: a review of studies and experimental methodology. Reilly JG, McTavish SF, Young AH. J Psychopharmacol. 1997;11(4):381-92.Links

45)  Does 5-HT restrain panic? A tryptophan depletion study in panic disorder patients recovered on paroxetine. Bell C, Forshall S, Adrover M, Nash J, Hood S, Argyropoulos S, Rich A, Nutt DJ. J Psychopharmacol. 2002 Mar;16(1):5-14.

46)  The therapeutic potential for tryptophan and melatonin: possible roles in depression, sleep, Alzheimer's disease and abnormal aging. Maurizi CP. Med Hypotheses. 1990 Mar;31(3):233-42.

47)  Why not treat melancholia with melatonin and tryptophan and treat seasonal affective disorders with bright light? Maurizi CP. Med Hypotheses. 1988 Dec;27(4):271-6.

48)  Treatment of depression and sleep disorders. Significance of serotonin and L-tryptophan in pathophysiology and therapy Riemann D, Vorderholzer U. Fortschr Med. 1998 Nov 20;116(32):40-2.

49)  L-tryptophan. An essential amino acid for structural and functional metabolism. Loew D. Fortschr Med. 1997 Jan 30;115(3):40-2.

50)  L-tryptophan: a rational anti-depressant and a natural hypnotic? Boman B. Aust N Z J Psychiatry. 1988 Mar;22(1):83-97.

51)  L-tryptophan: a rational hypnotic with clinical potential. Hartmann E. Am J Psychiatry. 1977 Apr;134(4):366-70.

52)  Evaluation of L-tryptophan for treatment of insomnia: a review. Schneider-Helmert D, Spinweber CL. Psychopharmacology (Berl). 1986;89(1):1-7.

53)  Interval therapy with L-tryptophan in severe chronic insomniacs. A predictive laboratory study. Schneider-Helmert D. Int Pharmacopsychiatry. 1981;16(3):162-73.

54)  Treatment of severe chronic insomnia with L-tryptophan: results of a double-blind cross-over study. Demisch K, Bauer J, Georgi K, Demisch L. Pharmacopsychiatry. 1987 Nov;20(6):242-4.

55)  The efficacy of L-tryptophan in the reduction of sleep disturbance and depressive state in alcoholic patients. Asheychik R, Jackson T, Baker H, Ferraro R, Ashton T, Kilgore J. J Stud Alcohol. 1989 Nov;50(6):525-32.

56)  Dietary influences on neurotransmission. Zeisel SH. Adv Pediatr. 1986;33:23-47.

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